详细信息
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ISI Export Format
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Qiang, XL Kou, Z
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Qiang, Xiaoli Kou, Zheng
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Prediction of interspecies transmission for avian influenza A virus based on a back-propagation neural network
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MATHEMATICAL AND COMPUTER MODELLING
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English
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Proceedings Paper
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4th International Conference on Bio-Inspired Computing
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OCT 16-19, 2009
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Beijing, PEOPLES R CHINA
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Dalian Univ, Zhengzhou Univ, Light Ind, IEEE Beijing Sect
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Peking Univ
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Avian influenza A virus; BP neural network; Interspecies transmission
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H5N1 VIRUS; HONG-KONG; INFECTION; CHINA; H9N2; ASIA
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Avian influenza A viruses could cross the barrier and infect human beings. We need to predict which subtypes and strains of avian influenza virus will become capable of interspecies transmission, which is very important for public health. Recently, two categories of molecular patterns, which were associated with the phenotype of interspecies transmission, were found to exist among avian influenza A viruses with different subtypes. In this study, we used a method based on wavelet packet decomposition to transform the viral sequences and used the energy features of the viral genome as input to train a back-propagation (BP) neural network. The average output values for test samples were 0.0125 and 0.0092. The good results of the experimentation were used to discriminate the two categories of molecular patterns. A novel method was constructed to predict the transmissibility of avian influenza A viruses, which is very useful for public health. It was also anticipated that the current classification method would be a useful tool based on the development of large-scale genome sequencing of the influenza A virus. (C) 2010 Elsevier Ltd. All rights reserved.
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1 [Kou, Zheng] Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China. [Qiang, Xiaoli] Peking Univ, Sch Elect Engn & Comp Sci, Beijing 100871, Peoples R China. [Qiang, Xiaoli] Peking Univ, Key Lab High Confidence Software Technol, Minist Educ, Beijing 100871, Peoples R China. [Qiang, Xiaoli] S Cent Univ Nationalities, Coll Comp Sci, Wuhan 430074, Peoples R China.
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Kou, Z, Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China.
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xlqiang@pku.edu.cn kouz2004@sohu.com
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BUTT KM, 2005, J CLIN MICROBIOL, V43, P5760, DOI 10.1128/JCM.43.11.5760-5767.2005 CHEN H, 2006, P NATL ACAD SCI USA, V103, P2845, DOI 10.1073/pnas.0511120103 CLAAS ECJ, 1998, LANCET, V351, P472 FOUCHIER RAM, 2004, P NATL ACAD SCI USA, V101, P1356, DOI 10.1073/pnas.0308352100 KOU Z, 2008, CHINESE SCI BULL, V53, P2002, DOI 10.1007/s11434-008-0236-2 KUIKEN T, 2005, SCIENCE, V309, P1680, DOI 10.1126/science.1113310 KUIKEN T, 2006, SCIENCE, V312, P394, DOI 10.1126/science.1122818 LI KS, 2004, NATURE, V430, P209, DOI 10.1038/nature02746 LIN YP, 2000, P NATL ACAD SCI USA, V97, P9654 LIO P, 2003, BIOINFORMATICS, V19, P2 SHU YL, 2006, NEW ENGL J MED, V354, P1421 SUBBARAO K, 1998, SCIENCE, V279, P393 XU XY, 1999, VIROLOGY, V261, P15 ZHU QY, 2006, NEW ENGL J MED, V354, P2731
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14
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0
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PERGAMON-ELSEVIER SCIENCE LTD
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OXFORD
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THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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0895-7177
J9
9 MATH COMPUT MODELLING
JI
Math. Comput. Model.
PD
DEC
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2010
VL
52
IS
11-12
BP
2060
EP
2065
DI
10.1016/j.mcm.2010.06.008
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6
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Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering; Mathematics, Applied
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647JK
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ISI:000281614600018
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