Qiang, Xiaoli Kou, Zheng
Prediction of interspecies transmission for avian influenza A virus based on a back-propagation neural network
MATHEMATICAL AND COMPUTER MODELLING
4th International Conference on Bio-Inspired Computing
Beijing, PEOPLES R CHINA
Dalian Univ, Zhengzhou Univ, Light Ind, IEEE Beijing Sect
Avian influenza A virus; BP neural network; Interspecies transmission
H5N1 VIRUS; HONG-KONG; INFECTION; CHINA; H9N2; ASIA
Avian influenza A viruses could cross the barrier and infect human beings. We need to predict which subtypes and strains of avian influenza virus will become capable of interspecies transmission, which is very important for public health. Recently, two categories of molecular patterns, which were associated with the phenotype of interspecies transmission, were found to exist among avian influenza A viruses with different subtypes. In this study, we used a method based on wavelet packet decomposition to transform the viral sequences and used the energy features of the viral genome as input to train a back-propagation (BP) neural network. The average output values for test samples were 0.0125 and 0.0092. The good results of the experimentation were used to discriminate the two categories of molecular patterns. A novel method was constructed to predict the transmissibility of avian influenza A viruses, which is very useful for public health. It was also anticipated that the current classification method would be a useful tool based on the development of large-scale genome sequencing of the influenza A virus. (C) 2010 Elsevier Ltd. All rights reserved.
1 [Kou, Zheng] Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China. [Qiang, Xiaoli] Peking Univ, Sch Elect Engn & Comp Sci, Beijing 100871, Peoples R China. [Qiang, Xiaoli] Peking Univ, Key Lab High Confidence Software Technol, Minist Educ, Beijing 100871, Peoples R China. [Qiang, Xiaoli] S Cent Univ Nationalities, Coll Comp Sci, Wuhan 430074, Peoples R China.
Kou, Z, Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China.
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Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering; Mathematics, Applied